By T. Haferlach, C. Schoch, W. Hiddemann (auth.), Prof. Dr. med. Wolfgang Hiddemann, Prof. Dr. Dr. med. phil. Torsten Haferlach, Dr. med. Michael Unterhalt, Prof. Dr. med. Thomas Büchner, Prof. Dr. med. Jörg Ritter (eds.)
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Extra resources for Acute Leukemias IX: Basic Research, Experimental Approaches and Novel Therapies
Pediatr Hematol Oncol16: 355-360. Gluzman DF, Abramenko IV, Sklyarenko LM et al. (2000) Leukemia diagnosis. Atlas and practical handbook. Morion, Kyiv (in Russian). Establishment of the 8-Cell Precursor-Acute Lymphoblastic Leukemia Cell Line MUTZ-S Carrying a (12;13) Translocation C. , R. F. MACLEODl, H. G. JANSSEN2, 1. G. DREXLER l Abstract Continuous leukemia-lymphoma cell lines are important research tools, in particular as starting material for the cloning of recurrent translocations. In 1998, we established the continuous leukemia cell line MUTZ-S.
Durst, K. , and Hiebert, S. W. (1999). The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor, Proc Nat! Acad Sci USA 96, 12822-7. , and Hiebert, S. W. (1998a). The MYND motif is required for repression of basal transcription from the multidrug resistance-I promoter by the t(8;21) fusion protein, Mol Cell BioI 18, 3601-3611. , Westendorf, I. , and Hiebert, S. W. (2000). A mechanism of repression by acute myeloid leukemia-I, the target of multiple chromosomal translocations in acute leukemia, I BioI Chern 275,651-6.
While this region is deleted in the t(8;21) (Fig. lA), it is retained in the t(12;21) (Fig. IB). Following the observation that the AML 1 associated with mSin3A, it was demonstrated that TEL! , 1999). , 1999). In addition, when the mSin3A interaction domain of AML-l was deleted, TEL! , 1999). , 2000) and Wang and Hiebert, unpublished data). AMLl makes multiple contacts with co-repressors to convert AML-l from a regulated to an unregulated transcriptional repressor (Fig. 2). The inv(16) fusion protein The inv(16) fuses near all of an AML-l binding protein, core binding factor beta (CBFB) to the C-terminus of a smooth muscle myosin heavy chain.