By Jan Lotvall
content material: Similarities and alterations within the pathophysiology of bronchial asthma and COPD / Christian Virchow --
Glucocorticoids : pharmacology and mechanisms / Peter Barnes --
Inhaled corticosteroids? medical results in bronchial asthma and COPD / Paul O'Byrne --
LABAS : pharmacology, mechanisms and interplay with anti inflammatory remedies / Gary Anderson --
lengthy and ultra-long performing beta-2-agonists / Mario Cazzola --
the protection of long-acting beta agonists and the advance of mixture treatments for bronchial asthma and persistent obstructive pulmonary disorder / Eugene Bleecker --
Inhaled mix remedy with glucocorticoids and long-acting beta-2-agonists in bronchial asthma and COPD, present and destiny views / Jan Lotvall --
Novel anti inflammatory remedies for bronchial asthma and COPD / Ian Adcock --
Novel biologicals on my own and together in bronchial asthma and allergic reaction / William Busse --
Anti-infective remedies in bronchial asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston --
lengthy appearing muscarinic antagonists in bronchial asthma and COPD / Denis O'Donnell --
Phosphodiesterase inhibitors in obstructive lung affliction / Jan Lotvall --
organic treatments in improvement for COPD / Riccardo Polosa --
Triple therapy?, within the administration of power obstructive lung illness (COPD). the worth of mixture remedy with inhaled steroid, lengthy performing anticholinergicbronchodilator and lengthy appearing beta 2 agonist bronchodilator in COPD / Ronald Dahl.
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Additional resources for Advances in combination therapy for asthma and COPD
Am J Respir Cell Mol Biol 2004;30:555–63. 39. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27:413–26. 40. Barnes PJ. Cortoicosteroid effects on cell signalling. Eur Respir J 2006;27(2):413–26. 41. Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J Endocrinol 2003;178:5–12. 42. Engelbrecht Y, de Wet H, Horsch K, Langeveldt CR, Hough FS, Hulley PA. Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
Eur Respir J 2005;25:552–63. 9. Adcock IM, Ford P, Barnes PJ, Ito K. Epigenetics and airways disease. Respir Res 2006;7:21. P1: OTA/XYZ JWST083-02 P2: ABC JWST083-L¨otvall 34 September 8, 2011 0:41 Printer Name: Yet to Come CHAPTER 2 10. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1␤-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000;20:6891– 903. 11. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family.
37. Newton R, Staples KJ, Hart L, Barnes PJ, Bergmann MW. GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms. Biochem Biophys Res Commun 2001;287:249–53. 38. Bergmann MW, Staples KJ, Smith SJ, Barnes PJ, Newton R. Glucocorticoid inhibition of GMCSF from T cells is independent of control by NF-B and CLE0. Am J Respir Cell Mol Biol 2004;30:555–63. 39. Barnes PJ. Corticosteroid effects on cell signalling. Eur Respir J 2006;27:413–26. 40. Barnes PJ.