By Zeliha Yazici, Giancarlo C. Folco, Jeffery M. Drazen, Santosh Nigam, Takao Shimizu
This quantity, the lawsuits of the twelfth foreign convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid learn: simple technological know-how and scientific functions, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid examine with exact realization to melanoma, cardiovascular illnesses, gastrointestinal ailments and respiration illnesses. particular subject matters coated comprise the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Additional resources for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
Within the niches of the bone marrow microenvironment, survival and proliferation of hematopoietic progenitors depend on a close relationship between hematopoietic and stromal cells. Serum-free liquid cultures were set up to address a potential role of cysteinyl leukotrienes within this compartment as mediators of HPC proliferation and/or differentiation. 3 % (mean ± SEM) in cultures containing 100 nM LTD4 compared to cytokines alone. In this system, the effect of LTD4 on HPC proliferation was dependent on the presence of IL-3.
Circulation 1995; 92: 3304-11. Panettieri RA, Tan EM, Ciocca V Luttmann MA, Leonard TB, Hay DW. Effects of LT04 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists . Am J Respir Cell Mol Bioi 1998; 19: 453-61. Porreca E, Di Febbo C, Di Sciullo A, Angelucci 0, Nasuti M, Vitullo P, Reale M, Conti P, Cuccurullo F, Poggi A. Cysteinyl leukotriene 04 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia.
In the regulation of adhesive phenomena in cerebral microcirculation in vivo. We used a newly developed model of intravital microscopy in mice, allowing analysis of the interactions (rolling and firm. adhesion) between PMNL and endothelium in brain microvasculature. Using this in vivo model and the highly specific leukotriene biosynthesis inhibitor MK886, we demonstrate that cys-LT playa role in the regulation of fum adhesion of PMNL to the endothelium in inflamed cerebral venules. Methods Human PMNL were purified as described .