Download AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo PDF

By Flossie Wong-Staal, Robert C. Gallo

This reference describes the newest advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing ideas to lessen the development and transmission of AIDS. With contributions through universally famous professionals within the box, AIDS Vaccine examine discusses

  • major stumbling blocks within the id of a preventive vaccine
  • the position of innate immunity in administration of HIV an infection
  • the impression of hugely energetic antiretroviral treatment (HAART) on AIDS learn
  • the construction of an efficient mucosal DNA vaccine
  • the influence of the AIDS epidemic on constructing international locations supplying approximately 2000 modern references to facilitate extra examine, AIDS Vaccine examine is a well timed handbook appropriate for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate scholars in those disciplines.
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    However, quantitative studies of the frequency of HIV-infected cells in vivo suggest that single cell killing by direct infection with HIV may not be the predominant mechanism of CD4ϩ T cell depletion (159,400). Although it increases with disease progression, the frequency of HIVinfected peripheral blood CD4ϩ T cells rarely exceeds 1 in 100 even in patients with AIDS (159,400–404). Viral burden and levels of virus expression are far greater in lymphoid tissue compared with peripheral blood (137,138,159); how- Immunopathogenesis of HIV Infection 33 ever, these levels even in lymphoid tissue do not appear to be sufficiently high to account for CD4ϩ T-cell depletion solely by direct mechanisms.

    Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J Biol Chem 271:17161–17166. , R.

    1996. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35:3362–3367. K. L. M. Murphy. 1996. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol 60:147–152. , J. Gosling, V. Schweickart, P. Gray, I. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. J Biol Chem 271:17161–17166.

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