By Wojciech Gorczyca
This broad reference protecting neoplastic hematopathology contains over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and more often than not affected extranodal organs, with detailed emphasis at the differential prognosis. It discusses easy medical, prognostic, morphologic and phenotypic info, with a number of tables summarizing the phenotypic profiles of the most typical hematologic tumors. a massive characteristic of this booklet is an method of hematologic tumors in line with the WHO class, with correct examples and emphasis at the Most worthy morphologic and immunophenotypic beneficial properties utilized in diagnosis.It may be a useful reference for all training hematologists, oncologists and pathologists.
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Additional resources for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
Positive expression of marker(s) not associated with the specific cell type (or the absence of an antigen which is normally positive) is termed aberrant antigen expression. Identification of an aberrant phenotype is used in FC evaluation of hematopoietic malignancies14,20–23,29,31,32,37–39. 15 presents several examples of aberrant antigen expression. 15A shows a peripheral T-cell lymphoma with aberrant expression of CD20 (arrow) on a subset of T-cells. 15B shows a diffuse large B-cell lymphoma with aberrant expression of CD56.
21 shows examples of PCR studies. NORMAL STRUCTURE OF HEMATOLYMPHOID ORGANS The hematolymphoid system, in which leukemia and lymphoma arise, consists of lymph nodes, the bone marrow, the spleen and the thymus. Atlas of differential diagnosis in neoplastic hematopathology 40 Lymph node The lymph nodes act as a scaffolding system and home for lymphocytes and monocytes/histiocytes in the lymphatic system. 22A). Primary and secondary follicles are distributed within cortex (at the periphery of the lymph node).
Dim CD20 expression Introduction 27 is typical for B-CLL/SLL, and bright CD20 is observed in HCL. Other B-cell lymphoproliferations show moderate CD20. Coexpression of CD5 and CD23 is most typical for B-CLL/SLL. CD25 is seen in all typical HCL, which are also positive for CD103 and CD11c. Other B-cell lymphomas are CD25+, and therefore expression of this antigen is not specific for HCL. CD43 is useful in differentiating FL (CD43−) from Burkitt lymphoma (CD43+). These two lymphomas differ also in expression of bcl-2.